Shahid Beheshti
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Efficacy of Intraoperative Mitomycin-C in Vasovasostomy Procedure

Two-six percentage of vasectomized men will ultimately seek vasectomy reversal, which late stricture
and obstruction after operation are relatively common. To find a method for improving vasovasostomy outcomes, we
used intra-operative local mitomycin-C (MMC) preventing possible fibrosis and stricture. In this randomized clinical trial, 44 patients were assigned to two groups randomly during a one-year study and the data of 40 patients were analyzed. The patients were followed up for 6 months after surgery. The case group (n=19) was treated by vasovasostomy with intra-operative local MMC. The control group (n=21)
underwent standard vasovasostomy.

Mean sperm count in MMC group was significantly higher than the controls. The sperm count of more than
20 million/ml was respectively 53% and 14% in MMC and control groups. In a subgroup where the interval between
vasectomy and reversal was 5-10 years, post-reversal azoospermia was absent in MMC group, but 50% of the controls
were still azoospermic. In addition, 80% of MMC group had more than 20 million/ml sperms, but all of the controls
had less than 20 million/ml sperms. No significant complication was seen.
Intra-operative local MMC in vasovasostomy can be regarded as a safe and efficient technique which
has several advantages including lower cost. Increase of sperm count is the main effect of local MMC application
that is more prominent when the interval between vasectomy and reversal is 5-10 years (Registration number

 


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Men's Health and Reproductive Health Research Center

Shahid Beheshti University of Medical Sciences

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Address: Tajrish Sq., Shohada-e-Tajrish Hospital, Tehran, Iran

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Men's Health and Reproductive Health Research Center , Shahid Beheshti University of Medical Sciences , Tehran, Iran

     
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